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Typhoid Fever

Typhoid fever is a clinical disease that is caused by the bacteria called Salmonella typhi, causing high grade fever, headache, vomiting and diarrhea or constipation. The following are the treatment options available for Typhoid Fever.

Antibiotics Therapy

Antibiotics therapy is the only effective treatment for Typhoid fever. The most commonly prescribed antibiotics and the drug of choice for Salmonella typhi is Ciprofloxacin (Cipro) given for a period of 7 to 10 days to lead to the prompt eradication of the bacteria. Ciprofloxacin may not be given to pregnant women and children. The second line of antibiotics is Ceftriaxone (Rocephin), intravenous or intramuscular third generation cephalosporin to control Salmonella infection, especially children and pregnant mothers.

Antibiotic Resistance

In the past, the drug of choice for Typhoid fever is Chloramphenicol. However, many with Salmonella  developed resistance to the drug. Antibiotic resistance of common bacteria is one of the leading health problems in developing nations and third world countries. Recently, there have been strains of Salmonella resistant to Ampicillin and Cotrimoxazole antibiotics.

Supportive Therapy

Supportive care treatment is aimed at addressing the symptoms of the disease. Fluid therapy will prevent individuals from dehydrating due to frequent fluid loss, diarrhea and fever. Severely dehydrated individuals may need intravenous fluids. Healthy nutrition which is non-bulky but high in calories may help replace lost energy.


Individuals with complete antibiotic coverage may be symptom free in 2 to 4 weeks. The outcome of the disease is generally good, if treatment is started early. The outcome may be poor, if treatment is started late. There have been incidences of relapse reported in the case of Typhoid Fever.

It is important to recognize that medications and medical procedures are associated with benefits and risks that should be discussed with your physician. It is important to recognize that all information contained on this website cannot be considered to be specific medical diagnosis, medical treatment, or medical advice. As always, you should consult with a physician regarding any medical condition. Your Health Access disclaims any liability for the decisions you make based on this information.